Atletico Madrid finished pre-season with a 1-0 victory away to Leganes, Juan Moreno scoring the game's only goal.
AC Milan lost to Real Betis as the Spanish side answered Andre Silva's late penalty with a spot-kick of their own.
Eder, Stevan Jovetic and Marcelo Brozovic were all on target as Inter saw off LaLiga side Villarreal at the Stadio Riviera delle Palme.
Nico Gaitan, Fernando Torres and Lucas Hernandez were on target as Atletico Madrid beat Premier League newboys Brighton and Hove Albion 3-2.
In their first match since the sale of Neymar, Barcelona star Paco Alcacer produced a moment of magic to salvage a draw against Gimnastic.
Cristiano Ronaldo appeared extremely frustrated after Portugal's 1-0 defeat to Spain, but Bruno Fernandes came to his defense.