Bayern Munich have announced that Thomas Muller has tested positive for COVID-19.
The veteran forward contracted the virus for the first time in February 2021 following the Club World Cup in Doha.
Muller has now returned a positive coronavirus test for a second occasion, with the reigning Bundesliga champions confirming he will serve another period of self-isolation.
That likely rules him out of the clash with Eintracht Frankfurt on Saturday as Julian Nagelsmann's side look to extend their six-point advantage at the summit of the German top flight.
Muller may target a return for the meeting with Bayer Leverkusen on March 5, dependent on when he returns a negative test and comes back into training.
The Germany international's absence will serve as a blow for the Bavarian team, given he leads the assist charts this season across all competitions at Bayern (19).
Muller has 10 goals to his name - only Robert Lewandowski (39), Leroy Sane and Serge Gnabry (both 12) have managed more - and has created a team-leading 89 chances, 20 more than any team-mate.
The 32-year-old has played the most games for his side this term as well (33), and his absence will frustrate Nagelsmann, who is still without Manuel Neuer after he required knee surgery.
The goalkeeper did, however, return to light training on Monday so could provide a boost for Bayern in the near future, with Alexander Nubel currently deputising in goal.