Sevilla paid tribute to former captain Marcelo Campanal before the game, and goals from Lucas Ocampos and Fernando delivered a derby win.
Real Madrid can alter the outlook in LaLiga with a win in El Clasico on Saturday, having already beaten Barcelona once this season.
Luis Suarez is behind only Lionel Messi for LaLiga goals but he is facing a spell out after injuring his leg in Atletico Madrid training.
Pedri has become a first-team regular alongside Lionel Messi at Barcelona, but watching the captain in training is still an experience.
Zinedine Zidane was asked about reports linking him with former club Juventus after Real Madrid beat Liverpool on Tuesday.
Zinedine Zidane has seen his plans to face Liverpool impacted late on after a positive COVID-19 test for Raphael Varane.