Jan Oblak made a superb save in the second half as Atletico Madrid claimed a point from Sunday's clash with Real Betis to move top.
Lucas Vazquez sustained knee damage in Real Madrid's 2-1 win over Barcelona and is not likely to play again in 2020-21.
Real Madrid can alter the outlook in LaLiga with a win in El Clasico on Saturday, having already beaten Barcelona once this season.
Luis Suarez is behind only Lionel Messi for LaLiga goals but he is facing a spell out after injuring his leg in Atletico Madrid training.
Pedri has become a first-team regular alongside Lionel Messi at Barcelona, but watching the captain in training is still an experience.
Sevilla paid tribute to former captain Marcelo Campanal before the game, and goals from Lucas Ocampos and Fernando delivered a derby win.