Declan Rice has been withdrawn from the England squad for their latest round of World Cup qualifiers due to illness.
The midfielder has not been able to train since reporting to St George's Park and has returned to West Ham.
He will miss England's qualifiers with Albania and San Marino, from which they need four points to secure a place at the World Cup in Qatar.
England have not replaced Rice in the squad, with Mason Mount and Luke Shaw yet to join the group and still being assessed.
Chelsea midfielder Mount is recovering from dental surgery while Shaw suffered a concussion in Manchester United's defeat to Manchester City last Saturday.
Rice has been excellent form this season for a West Ham side just three points behind Premier League leaders Chelsea.
Of Premier League midfielders to have attempted 500 passes this season, only Rodri (92.3) has completed more than Rice (91.7).