Lorenzo Insigne and Vlad Chiriches face a race to be fit in time to feature for Napoli when they travel to Arsenal on April 11.
Pablo Machin has paid the price for Sevilla's Europa League elimination, having his tenure cut short as Joaquin Caparros steps in again.
Friday's Europa League draw saw the two Premier League sides kept apart in the last eight. Take a look at the full list of fixtures.
Chelsea and Arsenal were kept apart in the Europa League quarter-final draw, with the Gunners facing Napoli in the last-eight.
If Arsenal and Chelsea are drawn at home on the same day in the Europa League, the Gunners will have their fixtures reversed.
Luka Jovic returned to form as Eintracht Frankfurt beat Inter to secure their place in the Europa League quarter-finals.