Steven Gerrard guided Rangers to their first title in 10 years in 2020-21, but he has now left the Glasgow giants to join Aston Villa.
England will qualify for the World Cup with four points from the next two games, but will not have Declan Rice at their disposal.
Leicester City looked destined to beat Napoli in their Europa League Group C opener, but Victor Osimhen earned the Italian side a point.
In a landmark game for manager Steven Gerrard, Scottish champions Rangers were no match for a clinical Lyon side at Ibrox.
For half an hour, Celtic threatened to race away from Real Betis, only to ultimately come up short in their Europa League opener.
Manchester United dominated Copenhagen in the last eight of the Europa League but needed an extra-time penalty to advance.