Former Real Madrid and Juventus forward Gonzalo Higuain struggled on his Inter Miami debut.
Kacper Przybylko scored a brace as Philadelphia Union cruised past a 10-man Montreal Impact.
Linked with a move to Inter Miami, Gonzalo Higuain's Juventus exit has been confirmed.
Los Angeles FC climbed into fourth after a much-needed win over Portland Timbers in MLS.
Lewis Morgan's brace helped Inter defeat Atlanta United 2-1 in Miami on Wednesday.
Philadelphia Union midfielder Alejandro Bedoya called on Congress to protect USA's citizens after a spate of gun violence incident