Down a goal and a man after 57 minutes, Colorado Rapids rallied to stun Minnesota United.
Seattle Sounders are back on top in the west, while Inter Miami face a battle to reach the post-season.
Brian White's treble lifted Vancouver Whitecaps, while Atlanta United's post-season chances were dealt a blow.
Portland Timbers accounted for LAFC as Philadelphia Union ended a three-game winless streak.
Johnny Russell scored and assisted two others as Sporting KC found the back of the net at home for the 28th consecutive regular-season game.
Philadelphia Union midfielder Alejandro Bedoya called on Congress to protect USA's citizens after a spate of gun violence incident