Down a goal and a man after 57 minutes, Colorado Rapids rallied to stun Minnesota United.
Seattle Sounders are back on top in the west, while Inter Miami face a battle to reach the post-season.
Brian White's treble lifted Vancouver Whitecaps, while Atlanta United's post-season chances were dealt a blow.
Johnny Russell scored and assisted two others as Sporting KC found the back of the net at home for the 28th consecutive regular-season game.
Cristian Arango's brace included the fastest goal in LAFC history after opening the scoring just 20 seconds into the match.
Philadelphia Union midfielder Alejandro Bedoya called on Congress to protect USA's citizens after a spate of gun violence incident