Nani helped Orlando City move above Philadelphia Union, while MLS top scorer Raul Ruidiaz produced a special strike for Seattle Sounders
Inter Miami fell 5-0 to New England Revolution on Wednesday and Phil Neville is taking full responsibility for his side's latest loss.
Carles Gil was at his brilliant best as New England Revolution moved clear at the top, inflicting further pain on struggling Inter Miami.
Vancouver Whitecaps and Houston Dynamo combined for only one shot on target, with Maximiliano Urruti's free-kick coming closest.
Robin Lod scored an 81st-minute winner to end Seattle Sounders' undefeated streak, as they continue to stumble in MLS.
Philadelphia Union midfielder Alejandro Bedoya called on Congress to protect USA's citizens after a spate of gun violence incident