Rafael Nadal has withdrawn from the National Bank Open ahead of his opening match due to a left foot injury.

The Spaniard made a return to action on the ATP Tour last week at the Citi Open, his first outing since suffering defeat to Novak Djokovic in the semi-finals of the French Open in June.

His comeback was aimed at getting prepared for the US Open but, having lost in the last 16 in Washington to Lloyd Harris, he will not now be participating in Toronto.

"I really wanted to play here a lot, but now is the moment to make a decision, and this is unfortunately the decision that I have taken," Nadal told the media.

"I have had this issue for a couple of months, as people know.

"Of course, it is not a happy situation after all the success that I had here in Canada, not being able to play this year after missing a year. It's a tough one, but that's how it is today."

Nadal skipped Wimbledon citing the need to recover after the clay season, while the left-hander also opted out of representing his country at the Tokyo Olympics.

The five-time champion in Toronto was scheduled for a repeat meeting with Harris in the second round. Instead, his place in the draw goes to compatriot Feliciano Lopez.