Simona Halep revealed her Rome withdrawal this week was caused by a torn calf muscle, a blow that casts doubt on her prospects of playing the French Open.
Former world number one Halep had to be helped off court by coach Darren Cahill after she was injured while leading Angelique Kerber 6-1 3-3 in the second round of the Internazionali d'Italia on Wednesday.
The two-time grand slam champion on Friday announced the extent of her injury. Her misfortune comes with just over two weeks remaining until the clay-court grand slam at Roland Garros gets under way on May 30.
Wimbledon is the next major on the calendar after the Paris slam, with the All England Club tournament scheduled to start on June 28 in London.
"After an MRI here in Rome I can confirm that I have small tear high up in the left calf," Romanian Halep posted on her social media accounts.
"I will fly home today and begin recovery in the pool and gym on Monday.
"I'm staying positive and will do everything i can to speed up my return."
Halep, now 29 years old, won her first major title in Paris three years ago and went on to be crowned Wimbledon champion in 2019.