Serie A champions Inter saw off Roma 3-1 at San Siro on Wednesday to stretch their club-record winning home league run to 15 matches.
Antonio Conte's men had failed to beat Roma on home soil in the league since 2015, but they raced into a two-goal lead in this latest clash inside the opening 20 minutes.
Midfield pair Marcelo Brozovic and Matias Vecino both scored from clinical finishes before Henrikh Mkhitaryan pulled one back just after the half-hour mark.
Edin Dzeko hit the crossbar in the second half but Inter, who were crowned champions with four games remaining, rounded out the win through Romelu Lukaku late on to extend their unbeaten league run to 20 matches.
With the Scudetto already sealed, Conte continued with his rotation policy and two of Inter's recalled players linked up for the opener with 11 minutes played.
Matteo Darmian pulled the ball back from the byline and Brozovic fired a first-time finish away from Daniel Fuzato.
The Nerazzurri did not take long to double their lead through a well-taken Vecino strike following some good play from Lukaku to chase down a pass and wait for support.
Roma put five unanswered goals past bottom side Crotone on Sunday and they were back in this game thanks to Mkhitaryan's curled finish away from Ionut Radu.
The visitors almost levelled up 11 minutes into the second half when Dzeko turned in the box and arrowed a shot against the frame of the goal.
Bryan Cristante headed wide from a glorious position and Mkhitaryan volleyed another chance into the hands of Radu, but Lukaku sealed the points for Inter with a last-minute tap-in after being unselfishly teed up by substitute Achraf Hakimi on the counter.