Camille Lopez's first act after coming on was to score a match-winning drop goal to spare France's blushes against Argentina.
Conor Murray, Jacob Stockdale and Keith Earls crossed for tries as Ireland got up and running in the Six Nations at Murrayfield.
New Zealand responded to their defeat against Ireland by putting Italy to the sword in Rome, Jordie Barrett scoring four of 10 tries.
South Africa paid the price for letting England off the hook at Twickenham, where Eddie Jones' men gained revenge for a series loss in June.
Will Carling is back in the England fold, the retired ex-captain taking on a leadership role under coach Eddie Jones.
England wing Chris Ashton's red card for Sale Sharks has landed him with a seven-week ban.
After impressing in his first season with the Jaguares, Mario Ledesma has been given the Argentina job.
Wales great Sam Warburton, 29, has retired from rugby after admitting "my body is unable to give me back what I had hoped for".
Joe Schmidt is in no rush to come to a decision on whether to sign another deal with Ireland or seek pastures new next year.
After beating Italy last time out, France head coach Jacques Brunel has made just one change to his side, bringing in Francois Trinh-Duc.
After almost a year out of action due to a back injury, Leinster and Ireland's Jamie Heaslip has been forced to call it quits.
England are favourites for Six Nations glory once again, but Eddies Jones' men will face a tough challenge to make it three in a row.
England have named their squad for the Six Nations opener against Italy, a selection that includes eight uncapped players.
If Eddie Jones picks James Haskell in his Six Nations squad, the flanker will not be able to face either Italy or Wales due to suspension.
Scotland's Six Nations squad features a host of returning experienced players, such as Greig Laidlaw, David Denton and Scott Lawson.
The uncapped duo of Josh Adams and James Davies - younger brother of Jonathan - have been included in Wales' 39-man Six Nations squad.
Guy Noves has been sacked as France's rugby union coach, with Jacques Brunel immediately installed as his replacement.
New Zealand skipper Kieran Read is expected to be out until April, as he requires surgery on an injury sustained at the end of the season.
Glasgow Warriors led 17-5 at one stage but Montpellier fought back brilliantly to seal a 29-22 European Champions Cup success at Scotstoun.
Wales make five changes for their Test against South Africa, with Scarlets centre Hadleigh Parkes to make his debut.
After failing to meet the requirements of the graduated return to play protocol, Alex Dunbar has withdrawn from the Scotland squad.
France will stage the Rugby World Cup for a second time, 16 years after first hosting the tournament.
Wales head coach Warren Gatland insisted his team will get stronger with more time together - and believes you can see this first hand from Australia who have already had nine games together.
Eddie Jones has stuck with Henry Slade and Sam Underhill in his side to face the Pumas, while Elliot Daly has been passed fit.
South Africa will be hoping to catch the All Blacks cold when they lock horns in their World Cup opener in Japan.
A pulsating Perth contest ended all square at 23-23 between Australia and South Africa in the Rugby Championship.
New Zealand fought back to retain the Bledisloe Cup, Beauden Barrett's late try consigning Australia to a 35-29 defeat.
France's persistence finally paid off when Damien Chouly scored a late try in a confusing end to their clash with Wales.
Rob Howley said the players who started Wales' victory over Ireland last Friday deserve to keep their shirts in Paris.
Ben Te'o, Danny Care, James Haskell and Jonny May come into the England starting line-up for a game they will be expected to win easily.
Scott Barrett's first-half red card gave Australia the impetus to dismantle Bledisloe Cup rivals New Zealand in the Rugby Championship.
Cory Hill's ankle injury has given Adam Beard an opportunity to come back into the Wales starting line-up at Murrayfield.
Scotland will once more be without full-back Stuart Hogg when they take on Wales in the Six Nations this weekend.
British and Irish Lions duo Maro Itoje and Jonathan Joseph, as well as former skipper Chris Robshaw, have been called up by England.
First-half tries from Tomas Francis and Liam Williams helped Wales beat South Africa 20-11 for their ninth successive victory.
Wales coach Warren Gatland will attempt to mastermind a series victory in his native New Zealand after his success in the role in Australia.