With two of the NFL's best defenses on the field on Thursday at Arrowhead Stadium, touchdowns may be at a premium.

Denver Broncos' 'Serious Six' group of Von Miller, DeMarcus Ware, Shane Ray, Shaquil Barrett, Malik Jackson and Antonio Smith wreaked havoc on Ravens quarterback Joe Flacco and the Baltimore offense in their season-opener.

Meanwhile, the Kansas City Chiefs' defense, led by Justin Houston, Derrick Johnson, Jamell Fleming and Allen Bailey, made the Houston Texans' offense look inept.

The game could come down to the running backs, and that’s where the Chiefs have the advantage with Jamaal Charles over Denver's C.J. Anderson, who is battling injury and was held to 29 yards on 12 carries by the Ravens.

Manning should be able to join Brett Favre as the only quarterbacks in NFL history with 70,000 passing yards. Manning will reach that mark with 134 yards on Thursday.

While Thursday night’s game could be a defensive struggle, there should be plenty of eye-catching offense on show in Sunday's standout fixtures.

Seattle Seahawks (0-1) at Green Bay Packers (1-0)

The Packers hope for a better result than last season’s NFC championship, when they watched the game slip away from them because of blown coverage and special teams miscues.

The Seahawks claimed an improbable 28-22 overtime victory over the Packers in Seattle to move onto Super Bowl XLIX.

Much of the focus will be on Seattle's secondary, minus starting safety Kam Chancellor, against Packers quarterback Aaron Rodgers, but the key to the game could be the Packers secondary against Seahawks quarterback Russell Wilson.

Wilson exploited Packers DBs, especially the safeties, to lead January’s comeback. The Packers could again be without starter Morgan Burnett, meaning Micah Hyde would start as he did in the opener at Chicago. The Packers' safeties, specifically second-year player HaHa Clinton-Dix, must play more disciplined against Seattle’s read-option and make sure tackles.

The Packers were gashed by Bears running back Matt Forte last Sunday, and it won't be any easier against Seattle's powerful back Marshawn Lynch.

New England Patriots (1-0) at Buffalo Bills (1-0)

Tom Brady was nearly perfect in last Thursday’s opener against the Pittsburgh Steelers, who could not stop Patriots tight end Rob Gronkowski. Buffalo presents a challenge for New England’s high-powered offense.

When the two teams met last December, the Bills sacked Brady four times in a 17-9 victory. Buffalo's defense was impressive in a 27-14 season-opening win over Andrew Luck and the Indianapolis Colts and will see the return of defensive tackle Marcell Dareus, who was suspended for the opener.

The Patriots started three rookies on their offensive line in the 28-21 win over the Steelers. The Bills have a much stronger defensive front and that could pose problems for the Patriots' young linemen.

Look for the Patriots to use extended running plays in the form of quick passes to slow down Buffalo's relentless pass rush led by Mario Williams, Jerry Hughes and Dareus.

While new Bills coach Rex Ryan is expecting a raucous crowd at Ralph Wilson Stadium, the Bills haven't enjoyed much of a home-field advantage against the Patriots. New England have won 10 of the last 11 matchups in Orchard Park.

Dallas Cowboys (1-0) at Philadelphia Eagles (0-1)

There is a certain running back everybody's eyes will be on in this one. After leading the NFL in rushing last season for the Cowboys, DeMarco Murray bolted in free agency for Philadelphia. Chip Kelly’s new-look offense, with Murray and quarterback Sam Bradford, struggled to find any consistency against the Atlanta Falcons, who applied constant pressure and dominated the Eagles' offensive line.

Dallas lost rookie defensive end Randy Gregory in their 27-26 win over the New York Giants, but the Cowboys still have the means to apply pressure on Bradford with DeMarcus Lawrence and Tyrone Crawford up front.

The Eagles defense picked off Atlanta quarterback Matt Ryan twice but also saw him throw for 298 yards and two touchdown tosses to Julio Jones, who could not be stopped. Cowboys quarterback Tony Romo turned in a superb effort against the Giants with 356 passing yards and three touchdowns, including the winning drive in the final minutes.

The Cowboys are without top receiver Dez Bryant, but could lean on tight end Jason Witten - who has five career 100-yard receiving games against the Eagles - and running back Lance Dunbar in the short passing game as they did against the Giants.

Tennessee Titans (1-0) at Cleveland Browns (0-1)

Tennessee Titans quarterback Marcus Mariota looked superb on his NFL debut with four touchdown passes in a 42-14 win over the Tampa Bay Buccaneers. Mariota became the first rookie quarterback to score a perfect rating in Week 1. The reigning Heisman Trophy winner from Oregon outdueled 2013 Heisman winner Jameis Winston and should get a shot at 2012 winner Johnny Manziel. It’s the first time in NFL history the most recent Heisman winner began his NFL career against the previous two Heisman recipients.

Manziel was dynamic on his opening series after entering the 31-10 loss to the New York Jets when Week 1 starter Josh McCown left with a concussion. Manziel threw a 54-yard pass to Travis Benjamin on his third pass. But he later threw an interception and finished the game with 182 yards on 13 of 24 passing and three total turnovers.