World number one Naomi Osaka could meet Serena Williams in the French Open quarter-finals, while defending champion Simona Halep will start against Ajla Tomljanovic.
Osaka is chasing a third consecutive grand slam title at Roland Garros, having triumphed at the US Open last year and the Australian Open in January.
The Japanese will face Anna Karolina Schmiedlova in the first round before the prospect of a tricky clash against either 2017 champion Jelena Ostapenko or two-time Melbourne winner Victoria Azarenka.
Osaka's task will only become tougher as she advances through the tournament, with a potential meeting with Williams, who boasts 23 major titles, in the last eight.
Williams, who withdrew from the Internazionali d'Italia last week after one match, plays Vitalia Diatchenko first.
Meanwhile, Halep will also be required to come through a blockbuster quarter-final if she is to win a second grand slam at the scene of her first triumph.
Sixth seed Petra Kvitova could await Halep in the fifth round.
A standout opening match sees Venus Williams play Elina Svitolina, with one of the pair possibly facing 2016 champion Garbine Muguruza in the third round.
Karolina Pliskova, Angelique Kerber and Caroline Wozniacki are all in the bottom quarter of the draw.