Mourinho sacked: Pogba, Ronaldo and Jose's biggest bust-ups

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So, the Jose Mourinho era at Manchester United has come to an end and perhaps too has the Portuguese's association with the Premier League.

The Red Devils opted on Tuesday to part ways with Mourinho, with United 19 points adrift of leaders Liverpool following a 3-1 defeat at their fierce rivals on Sunday, which left them sixth.

Mourinho's tenure at Old Trafford has been teetering on a cliff edge pretty much all season, a situation not helped by United's dismal Premier League performances.

But off-the-field issues have not helped his cause either amid reports of clashes with key players, most notably star midfielder Paul Pogba.

Pogba is not the first player to get on the wrong side of Mourinho and we have reviewed some of the former Real Madrid and Inter coach's best bust-ups.

Paul Pogba

THE BUST-UP: Pogba has seemingly won the battle with Mourinho. During this season, the World Cup winner often fell foul of his now former manager. A series of outspoken interviews from the France international led to him being stripped of the vice-captaincy and a terse training-ground exchange, picked up by television cameras. 

WHAT HAPPENED NEXT: Continued denials of a fall out did little to assuage the reports, and Pogba has flitted in and out of Mourinho's plans – notably not even coming off the bench in Sunday's loss to Liverpool, which ultimately spelled the end for Mourinho and possibly began a new start for Pogba at Old Trafford.

Iker Casillas

THE BUST-UP: As Mourinho confronted Pep Guardiola's all-conquering Barcelona team at Real Madrid, he could not allow any potential marginal gain to slip from his grasp. If this meant upsetting a club great, so be it, and Casillas' close friendship with his Spain team-mates in the Barca side reportedly angered the Portuguese. Madrid took LaLiga back in 2012 but the effort seemed to leave the dressing room drained and frayed. Casillas was dropped in December 2012 and, on his return from an injury, new signing Diego Lopez was preferred amid allegations the senior goalkeeper was the source of stories leaked to the Madrid press documenting disagreements between Mourinho and senior players.

WHAT HAPPENED NEXT: The dispute loomed large over Mourinho's departure at the end of the 2012-13 campaign, but Casillas never regained first-choice status and, after helping Madrid to Champions League glory in 2013-14, he signed for Porto in 2015.

Cristiano Ronaldo

THE BUST-UP: The two countrymen generally kept their relationship on a level in public during what were arguably the five-time Ballon d'Or winner's peak playing years, even though mediation from their mutual agent Jorge Mendes was reportedly required. But the Casillas affair took a wider toll in terms of Mourinho's standing with his senior players, with Ronaldo among those to renege on an uneasy truce.

WHAT HAPPENED NEXT: Following his Madrid departure, Mourinho seemed to relish the opportunity to send a barb in Ronaldo's direction. "He did not accept what I had to say. That might be because he thinks he already knows everything," Mourinho reflected when discussing his tactical criticism of Ronaldo. He referred to Brazil international Ronaldo as the "real" Ronaldo, while he dismissed the prospect of Cristiano signing for United this year as "never on the table".

Kevin De Bruyne

THE BUST-UP: De Bruyne began the 2013-14 season in Mourinho's Chelsea starting line-up, having impressed on loan at Werder Bremen. He fell from favour and, after Mourinho criticised his performance in a League Cup win at Swindon Town, the Belgium midfielder sought pastures new for fear of ending up on Chelsea's loan carousel. He signed for Wolfsburg in January of that season.

WHAT HAPPENED NEXT: Adapting quickly to his new surroundings, De Bruyne was named Bundesliga Player of the Season in 2014-15 as Wolfsburg finished as runners-up to Bayern Munich. That persuaded Manchester City to make the playmaker their then record signing and he was integral to their dominant Premier League triumph under Guardiola last term.

Eden Hazard

THE BUST-UP: Amid Chelsea's shambolic Premier League title defence in 2015-16, Mourinho's relationship with Hazard came to appear strained. After the forward impressed in a 2-0 Champions League win over Porto, he reacted to his late substitution by shunning Mourinho's handshake. Five days later during a 2-1 loss to Leicester City, Hazard left the action after half an hour with a hip problem despite Mourinho cajoling him to return to the field.

WHAT HAPPENED NEXT: The Leicester loss left Chelsea hovering improbably above the relegation zone and Mourinho was sacked, with technical director Michael Emenalo citing "palpable discord" within the squad. Hazard bounced back as a standout performer in the Blues' 2016-17 Premier League title win under Antonio Conte.

Luke Shaw

THE BUST-UP: Shaw began Mourinho's United tenure as his first-choice left-back but was soon out in the cold, with Mourinho casting aspersions over his attitude, commitment and "football brain" in various broadsides. When Shaw was hauled off at half-time during last season's 2-0 FA Cup win over Brighton and Hove Albion and his manager said the decision was in "relation to trust… relation to class", there seemed no way back.

WHAT HAPPENED NEXT: Shaw refused to be cowed and has seen plenty of action at left-back this season, earning an England recall and signing a new five-year deal in October.