Pierre-Emerick Aubameyang, Alexander Lacazette, Willian and Alex Runarsson have all been absent due to coronavirus, Arsenal have confirmed.
Head coach Mikel Arteta explained Aubameyang and Lacazette were feeling unwell prior to the Gunners' lacklustre 2-0 defeat at new boys Brentford to begin their Premier League campaign last Friday.
It has now been confirmed the strike duo are part of a quartet who missed that game following a positive test for COVID-19, with each player at various stages of their recovery.
Aubameyang, who scored 10 goals in 29 Premier League outings last term, has now returned a negative result and could be in contention to feature against Chelsea on Sunday.
Willian's situation will be monitored ahead of the clash against his former club, but Lacazette and Runarsson have both been ruled out of the derby clash.
Arsenal also provided injury updates on Gabriel, Eddie Nketiah and Thomas Partey after being beaten by a newly promoted side in their opening league match of the season for the first time since 1976-77 against Bristol City.
Partey is expected to return to training at the end of August after sustaining an ankle injury in the pre-season friendly against Chelsea.
Nketiah, who suffered an ankle injury in the same game as his team-mate, will be back in training a couple of weeks later in September, while Gabriel is aiming to be back later this month.