LeBron James will miss the Los Angeles Lakers' game against the Sacramento Kings on Wednesday, his first absence of the NBA season.

The Lakers fell to a 114-104 home loss against the Phoenix Suns on Tuesday, despite 38 points from James, who was an impressive 16-for-24 from the field.

Defending champions the Lakers have lost five of their past seven games as injuries begin to pile up.

James was listed as probable to play ahead of the Phoenix game with a left ankle sprain suffered earlier in the season.

He will now sit out of the second game of a back-to-back when the Lakers travel to take on the Kings.

After having a rest and receiving some treatment, it is still expected James will play in his 17th straight All-Star Game on Sunday.

With Anthony Davis already ruled out, Kyle Kuzma and Marc Gasol missed out against the Suns.

"We play so well the last two games, we get back into a rhythm, and then we find out [on the day of the game] that two of our big guns were out," James said after the game, per ESPN.

"It is definitely deflating, especially when you were playing poorly [losing four in a row] and then you get in a good rhythm [with two wins]."

Missing time will not sit well with James, who last month insisted he did not believe in rest amid calls for him to be given a breather to cope with a gruelling schedule.

Despite their recent struggles, the Lakers are third in the Western Conference at 24-12, just behind the Suns (23-11).

Lakers coach Frank Vogel added: "I'm happy with how we are competing. 

"Our guys are giving great effort and great hustle and great fight. You understand there is a big picture here, and guys are keeping the big-picture mindset."

The surging Suns won despite an ejection for star shooting guard Devin Booker, who had 17 points before being removed in the third quarter.

Dario Saric had 21 points off the bench, 10 of those coming in the fourth quarter.

James, 36, is averaging 25.8 points, 8.0 rebounds and 7.8 assists per game this season, his third with the Lakers.