Andre Drummond struggled to describe a gruesome toenail injury without laughing after the Los Angeles Lakers lost another star player.

LeBron James (ankle) and Anthony Davis (calf) both remain on the sidelines, meaning the signing of Drummond - bought out by the Cleveland Cavaliers - came as a big boost to the defending NBA champions.

But the center, playing for the first time since February 12, lasted just 14 minutes in a 112-97 debut defeat to the Milwaukee Bucks on Wednesday.

Drummond was stepped on by Brook Lopez in the first quarter, he later revealed, and eventually succumbed to the injury in the second half after taking his sock off to assess the damage.

"In the first quarter when I came out, Brook stepped on my foot and I didn't really think anything of it," the two-time All-Star said.

"I came back in the second quarter and it was hurting a little bit more. After halftime, I finally took my sock off to look and my whole toenail was gone. It was all bad from there. I couldn't walk or run so I told coach to take me out."

X-rays returned negative results, meaning Drummond should avoid a lengthy lay-off, but the player was not entirely sure how to manage the injury.

He said: "What do you do for a toe? I don't know. I'm not really sure what to do. I'm just going to talk to the training staff and find out what's the best thing to do to get back as quick as possible.

"I've lost a toenail before, but this one was very painful.

"You see me looking down at it because I can't even put shoes on. I have flip-flops on right now. It's very, very painful."

Despite his limited minutes, Drummond showed what the Lakers might be able to expect when he can return to the court.

The 27-year-old had four points, two assists, a rebound and a block.

He also missed two free throws - Drummond's career percentage of 46.6 per cent is the worst of all players to attempt 1,000 or more - but felt he had a positive impact overall.

"If you saw the first couple of minutes of the game that I was out there, just the energy defensively that I brought, it kind of boosted everybody on both ends of the court," Drummond said, although his plus/minus was negative eight.

"It's just unfortunate to have this happen to me in my first game. It was a little deflating for me.

"But my head is high, I'm going to take it day by day and come back better than ever."

Coach Frank Vogel, eager not to mull on more fitness problems as the Lakers fell to 30-18, added: "We've got a 'next man up' mentality with this group.

"Obviously we were all excited to see Dre in a Lakers uniform and it didn't play out as long as we wanted."