Stephen Curry's 35 points were not enough for the Golden State Warriors, while the Houston Rockets started the post-James Harden era with a win.
Curry was 14-of-23 from the field and five-of-11 from three-point range, but the Warriors fell to the Denver Nuggets 114-104 on Thursday.
Nuggets star Nikola Jokic dominated with a triple-double of 23 points, 14 rebounds and 10 assists.
Denver had seven players in double-digits for points as they improved to 6-6 – the same record the Warriors now hold.
After trading Harden to the Brooklyn Nets, the Rockets recorded a 109-105 win over the San Antonio Spurs.
Christian Wood had a double-double of 27 points and 15 rebounds for the Rockets, who were without John Wall (knee).
Milton magical for Sixers, Boucher lifts Raptors
Shake Milton had 31 points off the bench in the Philadelphia 76ers' 125-108 win over the Miami Heat. He was 11-of-15 from the field and three-of-four from three-points range.
Ben Simmons notched a triple-double of 10 points, 12 assists and 10 rebounds for the 76ers. Only Oscar Robertson (75 games) and Magic Johnson (190 games) have reached 30 career triple-doubles quicker than Simmons (228).
Chris Boucher had 25 points and 10 rebounds off the bench to help the Toronto Raptors beat the Charlotte Hornets 111-108.
A huge game from Domantas Sabonis (23 points and 15 rebounds) saw the Indiana Pacers past the Portland Trail Blazers 111-87.
After another four blocks and one steal, Pacers center Myles Turner reached 50 blocks and 18 steals through 12 games. He is the first player to have at least that many blocks and steals through his first 12 games of a season since David Robinson in 1992-93, as per Stats Perform.
Job done for 76ers despite Embiid struggles
Joel Embiid has enjoyed a superb start to the season, but the 76ers star struggled against Miami. He was three-of-eight from the field for just nine points in 23 minutes.
Miles Bridges produced a huge dunk during the Hornets' loss to the Raptors. He finished with 12 points.
Philadelphia 76ers 125-108 Miami Heat
Toronto Raptors 111-108 Charlotte Hornets
Houston Rockets 109-105 San Antonio Spurs
Indiana Pacers 111-87 Portland Trail Blazers
Denver Nuggets 114-104 Golden State Warriors
Pelicans at Lakers
The Los Angeles Lakers (10-3) are riding a four-game winning streak ahead of hosting the New Orleans Pelicans (4-6) on Friday. LeBron James is averaging 24.3 points, 8.1 rebounds and 7.5 assists per game to begin the campaign.