Tottenham lost Lucas Moura and Steven Bergwijn to injury as they played out a 2-2 draw with Ligue 1 side Rennes in Thursday's opening Europa Conference League match.
Lucas played a big part in Tottenham's opener, which was credited as a Loic Bade own goal, before having to make way following a poor challenge from Flavien Tait.
It was Tait who had earlier equalised for Rennes with a curled finish at an atmospheric Roazhon Park, shortly before Bergwijn was withdrawn with an apparent ankle issue.
Gaetan Laborde completed the turnaround 19 minutes from time, only for substitute Pierre-Emile Hojbjerg to quickly hit back and earn Spurs a point in the Group G clash.
Tanguy Ndombele was brought into the Tottenham side for his first appearance under Nuno Espirito Santo and played a huge part in the opening goal with 11 minutes played.
The Frenchman kept the ball in play with a fancy backheeled pass in a swift move that culminated in Lucas' attempted cross hitting Bade's boot and wrong-footing Romain Salin.
Serhou Guirassy then had a shot saved by Pierluigi Gollini but exchanged passes with Tait soon after for his team-mate to curl one into the bottom-right corner for the equaliser.
That ended Rennes' 212-minute wait for a goal and the hosts spurned a big chance to edge in front before half-time when Kamaldeen Sulemana headed wide from close range.
The second half had a disrupted feel to it following a number of fouls, one of which led to Lucas' injury, with the Spurs attacker unable to run off the damage.
That all changed when Laborde converted a rebound after Gollini pushed Sulemana's shot into his path, but it took Nuno's side just five minutes to respond through Hojbjerg's poked finish from close range to ensure the points were shared.
UEFA Europa Conference League results
HJK Helsinki (FIN) 0 LASK (AUT) 2 (Maresic 17, Monschein 89)
Flora Tallinn (EST) 0 Gent (BEL) 1 (Lemajic 54)
Anorthosis (CYP) 0 Partizan Belgrade (SRB) 2 (Menig 42, Ricardo Gomes 68)
Bodo/Glimt (NOR) 3 (Saltnes 48, Solbakken 49, Pellegrino 60) Zorya Luhansk (UKR) 1 (Gromov 90+1)
Roma (ITA) 5 (L. Pellegrini 25, 62, El Shaarawy 38, Mancini 82, Abraham 84) CSKA Sofia (BUL) 1 (Carey 10)
Randers (DEN) 2 (Piesinger 27, Jenson 68) AZ Alkmaar (NED) 2 (Clasie 24, Pavlidis 34)
Jablonec (CZE) 1 (Pilar 44-pen) CFR Cluj (ROM) 0
Slavia Prague (CZE) 3 (Bah 18, Kuchta 84, Schranz 88) Union Berlin (GER) 1 (Behrens 70)
Lincoln Red Imps (GIB) 0 PAOK (GRE) 2 (Akpom 45+2, Mitrita 56)
Slovan Bratislava (SVK) 1 (Henty 21) FC Copenhagen (DEN) 3 (Wind 18, 68-pen, Stage 41)
Mura (SLO) 0 Vitesse Arnhem (NED) 2 (Tronstad 30, Darfalou 69)
Rennes (FRA) 2 (Tait 23, Laborde 72) Tottenham (ENG) 2 (Bade 11-og, Hojbjerg 76)
Kairat Almaty (KAZ) 0 Omonia Nicosia (CYP) 0
Qarabag (AZE) 0 Basel (SUI) 0