Manchester United will be without Marcus Rashford for the first leg of their Europa League round-of-16 tie against Milan at Old Trafford.
Rashford limped off during the second half of Sunday's 2-0 derby victory over Premier League leaders Manchester City having suffered an ankle injury.
Ole Gunnar Solskjaer is not counting on the England forward for Thursday's showdown and believes he remains a doubt for the weekend visit of West Ham.
"I don't think he will be available," said Solskjaer. "He didn't join in training today.
"I think he is out of [the Milan game] and still a doubt for the weekend."
Rashford has 18 goals in all competitions this season, while his 10 assists are already the most he has managed in a campaign for United.
Although it ultimately had unfortunate consequences, Solskjaer felt the sight of the 23-year-old sprinting back to dispossess City winger Riyad Mahrez when incurring the injury demonstrated his overall value to the Red Devils' cause.
"That 60- or 70-yard recovery run showed the hunger, appetite, desire and humility in the team, so it was worth it, but you never like to lose players to injury," he said.
Edinson Cavani is also a doubt, having sat out the Manchester derby.
Quotes from the Uruguay striker's father emerged this week, suggesting he has decided he does not want to stay at Old Trafford beyond the end of this season and has his heart set on a move to Argentinian giants Boca Juniors.
But Solskjaer was not keen on being dragged into the debate.
"I can't comment on what has been said. I can only say that we are very pleased with Edinson when he is here. Day in and day out," Solskjaer said.
"He is proving his personality, his professionalism. He is really helping the young kids - as we wanted him to.
"He will make his decision. He knows we are very fond of what he has given to the club even if he has played less than he wanted to."
Milan arrive in Manchester with a depleted squad, without the likes of Zlatan Ibrahimovic, Hakan Calhanoglu and Theo Hernandez through injury.
It looks like Solskjaer will have to contend with similar selection headaches, after revealing Anthony Martial and Luke Shaw are nursing knocks after their starring roles in the derby victory.
Midfielders Donny van de Beek and Paul Pogba remain sidelined by muscular complaints, while David de Gea is absent once more having returned to Spain for the birth of his child. Dean Henderson is set to continue in goal.