Just weeks away from the start of the World Cup, the poor form of Europe's powerhouses suggests there could be a changing of the guard in Qatar.
European nations have won every World Cup since Brazil lifted the last of their five titles in Japan and South Korea in 2002.
Europe has supplied 13 of the 16 semi-finalists at the past four World Cups, with Italy, Spain, Germany and France coming out on top.
But reigning European champions Italy have failed even to qualify for Qatar, while there are doubts over the chances of England, France, Germany and Spain.
England's six-game winless run is their worst ever heading to a major tournament, with the Three Lions relegated from the top tier of UEFA's Nations League.
World champions France only avoided the same fate thanks to other results going their way as Les Bleus and Germany won just one of their six Nations League group games.
Spain have progressed to the semi-finals of that competition, but were beaten 2-1 at home by Switzerland last week.
- 'High-level opposition' -
Injuries, fatigue and the competitive nature of the Nations League have been pinpointed as the reasons for the struggles of some of the traditional giants.
England, Germany and Italy were all in the same Nations League group, as were Spain and Portugal.
"We're playing and have been playing some top-level sides and we will be better for that," said Southgate.
"In the past we've had runs of friendlies or whatever the matches are and then we've gone into tournaments. This is the first time we've hit high-level opposition."
France were without a host of stars that Didier Deschamps hopes will be fit for the World Cup for their 2-0 defeat to Denmark on Sunday.
"The important thing is to be able to recover all our strength in the next two months," said Deschamps.
As the European contenders struggle for continuity with little time to prepare, Argentina and Brazil head to Qatar as the form teams.
In what could be his final World Cup at 35, Lionel Messi is enjoying playing in the best Argentina side of his international career.
Lionel Scaloni's men are on a national record 35-game unbeaten run stretching back to 2019, which includes Messi's first major international trophy at the Copa America last year.
Defeat in that Copa America final on home soil is Brazil's only defeat in 29 matches.
The vast majority of those games for both nations have come against inferior opposition in friendlies and South American World Cup qualifiers.
But any questions over the quality of the current Argentina squad disappeared in a dominant 3-0 victory over Italy in June in the first-ever "Finalissima" between the champions of Europe and South America.
"I see Argentina above the rest and Brazil too," said Spain boss Luis Enrique. "Well above the rest."