Al-Hilal inched closer to the last 16 of the AFC Champions League thanks to Sebastian Giovinco, while Almoez Ali scored for Al Duhail.
Manabu Saito sealed a late AFC Champions League win for Kawasaki Frontale, but Hulk, Oscar and Elkeson were unable to inspire Shanghai SIPG.
Graziano Pelle struck twice to claim a 2-2 draw for Shandong Luneng at home to AFC Champions League holders Kashima Antlers on Tuesday.
Jeonbuk Motors started their AFC Champions League campaign with a comfortable win over Beijing Guoan, with Lee Dong-gook making history.
Al-Ittihad are the early front-runners in AFC Champions League Group B after a 5-1 win over Al Rayyan.
Former Barcelona star Xavi rolled back the years by scoring a brilliant free-kick in Al Sadd's AFC Champions League win over Pakhtakor.