Robert Lewandowski's 199th goal for Bayern Munich was not enough to claim the points as RB Leipzig fought back through Emil Forsberg's penalty to draw 1-1 in the Bundesliga on Saturday.
In their first meeting with Leipzig since a 3-0 DFB-Pokal final win in May, Lewandowski edged closer to a double century of Bayern goals to put Niko Kovac's side ahead.
But, after Bayern had a penalty overturned by VAR, Forsberg levelled matters from 12 yards on the stroke of half-time.
A rejuvenated Leipzig found Manuel Neuer in top form after the restart, though Bayern would have snatched it had Peter Gulacsi not managed to tip Kingsley Coman's deflected effort onto the woodwork as Leipzig held firm to move back into top spot after being briefly replaced by Borussia Dortmund.
Leipzig's support was in full voice before kick-off, but the home fans were silenced within three minutes when Lewandowski raced onto Thomas Muller's pass and coolly slotted beyond Gulacsi.
Lukas Klostermann wasted a chance to provide a swift response when he blasted over, while Lewandowski passed up two presentable opportunities.
Lewandowski looked set to have the chance to score his 200th Bayern goal when the visitors were awarded a penalty for a foul on Lucas Hernandez, but the referee changed his decision after a VAR check.
Bayern's frustrations were compounded in first-half stoppage time, Hernandez bringing down Yussuf Poulsen and Forsberg stepping up to tuck home from 12 yards.
Bayern would have restored their lead if not for a last-ditch block from Ibrahima Konate, before Neuer brilliantly denied Marcel Sabitzer on the hour.
Gulacsi made an outstanding save of his own soon after, denying Corentin Tolisso, with Timo Werner drilling wide at the other end.
Leipzig's goalkeeper had the final say, though, preventing Coman's strike looping in before he appeared to get a hand to Niklas Sule's last-gasp header to ensure a deserved share of the spoils.
What does it mean? Bayern face genuine challengers again
Bayern just edged out Borussia Dortmund last term, while Leipzig came in third. There is now an undoubted top three in the Bundesliga and based on this display, Leipzig are more than capable of testing Bayern this season.
Whether that will translate into a title challenge remains to be seen, but with both Leipzig and Dortmund improving their squads, Bayern should not have a clear path to an eighth successive league crown.
Nagelsmann's tactical tweak pays off
Julian Nagelsmann has enjoyed a fine start to his tenure in charge of Leipzig, though his decision to start with a back three backfired in the first half.
The former Hoffenheim coach made a change to a back four at half-time in a switch that worked well in helping to push Bayern back and give Leipzig's creative players more space to operate.
Rare Thiago error leaves Bayern exposed
Making his 200th Bayern appearance, Thiago Alcantara gave away a simple pass in the build-up to Leipzig's penalty, causing panic in the visitors' defence before Hernandez clumsily bundled into Poulsen.
Bayern host Red Star Belgrade in their first Champions League outing of the season on Wednesday, a day after RB Leipzig face Benfica in the same competition.
Chance! Leipzig go close to take the lead! Timo Werner's deft backheel hits the side netting!
Goal! Leipzig level up just before the break! Emil Forsberg makes no mistake from the penalty spot!
Goal! Robert Lewandowski makes no mistake! Thomas Muller with a perfect through ball and the Polish striker finishes with ease! Bayern take an early lead!
Bayern get us underway in Leipzig!
Now for RB Leipzig! Fresh from a hat-trick before the international break, Timo Werner starts. Keep an eye out for midfielder Emil Forsberg, who has been one of the standout players in recent weeks!
Team news time! First up Bayern! Serge Gnabry and Thomas Muller return to the side. Phillipe Coutinho has to settle for a place on the bench!
Want to know a little more about Wunderkind manager Julian Nagelsmann? This handy video will help!
We take a closer look at Julian Nagelsmann's tactics ♜ pic.twitter.com/lsVfiugQZj— Bundesliga English (@Bundesliga_EN) September 14, 2019
Bayern Vs Leipzig has always been feisty in recent years!
It promises to be a big one! Will it be goals galore in Leipzig?
Hello! So here we go! A big-time clash in the Bundesliga, between the reigning champions Bayern Munich and pretenders to the throne RB Leipzig. Who will come out on top tonight?
Good evening! Welcome to the Live Updates of RB Leipzig vs Bayern Munich. Title rivals face-off in Leipzig in what will be an early test for Rotten Bullen coach Julian Narglesmann. As ever, join me for all the build-up, team news and goals as they go in from the game.