Ten-man RB Leipzig crashed to a 5-2 home defeat by Hoffenheim in a key clash for the Champions League places next season.
Swedish international Emil Forsberg was sent off for a foul on Florian Grillitsch just after the break with Hoffenheim already 3-0 up.
Mark Uth, Serge Gnabry and Pavel Kaderabek all scored as Leipzig's defence buckled in the opening 45 minutes.
Naby Keita pulled a goal back before the hour mark, but Uth scored his second goal with a header before midfielder Lukas Rupp hit Hoffenheim's fifth.
England Under-21 international Ademola Lookman, on loan from Everton, set up Dayot Upamecano to score Leipzig's second on 88 minutes.
The result leaves Hoffenheim fifth, just two points from the Champions League places, while six-placed Leipzig are four adrift