Carlos Alcaraz has withdrawn from the upcoming Madrid Open due to a wrist problem, casting his participation in the French Open into further doubt.

Alcaraz had to pull out of the Barcelona Open earlier this week, having sustained a right wrist injury in his opening-round win over Otto Virtanen.

The Spaniard received medical treatment during that victory before later confirming he would play no further part in the tournament.

And he has now followed that by withdrawing from the next ATP Masters 1000 event, where he won back-to-back titles in 2022 and 2023.

"There are some news that are incredibly hard to share," Alcaraz said in a statement on social media.

"Madrid is home, one of the most special places on my calendar, and that's why it hurts so much not to be able to play here for the second year in a row.

"It hurts especially not to be in front of my people, in a tournament that means so much. Thank you for the unwavering affection, and I hope we see each other soon."

Alcaraz is the second player to withdraw from Madrid on Friday, with Novak Djokovic having pulled out earlier in the day amid his ongoing injury issues.

World number one Jannik Sinner also remains a doubt ahead of travelling to the Spanish capital, though he would have the opportunity to extend his lead at the top of the rankings over Alcaraz by competing.