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Lautaro Martinez and Marcus Thuram were among the scorers at MAPEI Stadium, while Yann Bisseck, Manuel Akanji and Luis Henrique were also on target for the visitor.

Inter survived an early scare when Federico Dimarco cleared off the line from Ismael Kone, but took the lead in the 11th minute when the wing-back's corner was nodded in by Bisseck.

Bisseck was then thwarted on the line and Dimarco struck the crossbar before the host doubled its lead on 28 minutes, with the latter's cross turned in by Thuram.

Sassuolo thought it had pulled a goal back just before half-time, but Kristian Thorstvedt's close-range effort was ruled out for offside after a VAR review.

The Nerazzurri put the contest beyond doubt with two goals in the space of three minutes, as Martinez's drilled finish was followed by Akanji heading in another Dimarco corner.

Things went from bad to worse for the host when Nemanja Matic was dismissed for violent conduct in the aftermath of the fourth goal, while Henrique's fierce half-volley completed the rout two minutes from time.