Daniil Medvedev suffered a rare hard-court loss to an opponent outside the world's top 20 as Alejandro Davidovich Fokina sent him crashing out of the Canadian Open.

Third seed Medvedev was beaten 6-4 1-6 6-2 by world number 43 Davidovich Fokina, the Spaniard coming through a one-hour, 56-minute contest in Montreal.

Davidovich Fokina, who reached the semi-finals of the tournament in 2023, will now face either Karen Khachanov or Matteo Arnaldi for a place in the quarter-finals.

It was only Medvedev's third hard-court defeat to an opponent ranked outside the ATP's top 20 since the start of 2023, with the others both coming against Sebastian Korda.

Medvedev was not the only player to be on the receiving end of an upset on Thursday, as Japan's Kei Nishikori beat Stefanos Tsitsipas 6-4 6-4 for his first top-20 win since 2021.

However, things were far more comfortable for world number four Alexander Zverev, who crushed Jordan Thompson by a 6-1 6-1 scoreline to reach the second round.

Zverev won a huge 95% (18/19) of points behind his first serve, also slamming 20 winners past Thompson, who had previously led the duo's head-to-head series 2-1.