The midweek FA Cup fifth round fixtures will give several Premier League clubs the opportunity to make up for significant setbacks over the weekend.

Manchester United manager Erik ten Hag cannot afford another defeat after Saturday’s late drama against Fulham, while Chelsea must respond to Sunday’s Carabao Cup loss to Liverpool.

Here, the PA news agency looks at the talking points around the key fixtures.

United need a response

Saturday’s stoppage-time home defeat to Fulham has put Manchester United under pressure going into Wednesday’s trip to Nottingham Forest. With a trip to the Etihad up next on Sunday, United need a positive result to avoid going into a derby amid another round of crisis talks at Old Trafford. With Sir Jim Ratcliffe’s buy-in now complete and an overhaul of football operations under way, the pressure on Erik ten Hag will only ramp up, and he cannot afford to see their only remaining hope of silverware this season come to an end.

Liverpool to clear their hangovers

There were emotional celebrations for Liverpool and their outgoing manager Jurgen Klopp after Virgil van Dijk’s header late in extra time won the Carabao Cup with a 1-0 win over Chelsea. Victory keeps Liverpool, top of the league by one point from Manchester City, alive in their bid for a quadruple as they remain among the favourites for both the FA Cup and the Europa League. Even with 120 minutes in their legs from Wembley, few would bet against them in a home tie against Championship Southampton.

Chelsea to bounce back

Mauricio Pochettino told his Chelsea players they needed to feel hurt by their Carabao Cup final loss, in which their performance in extra time prompted Gary Neville to call them “blue billion pound bottle jobs” on Sky Sports. Pochettino is yet to get a consistent tune out of his expensively-assembled squad, and Sunday’s defeat means the Argentinian has lost all three major finals he has reached while managing in England. The FA Cup offers an opportunity to put that right and their first opportunity to show a response comes on Wednesday, when they are favourites to see off Championship Leeds at Stamford Bridge.

Guardiola looking forward to intense period

As Manchester City return to Kenilworth Road to face Luton, where they had to come from behind to win 2-1 in the league in December, Pep Guardiola said he was relishing the decisive part of the season as his side look to replicate last season’s historic treble. Few would blame him given City’s enviable habit of reeling off long winning runs at this stage of a campaign. “Tomorrow is a final, like every game in Premier League and of course in Champions League,” Guardiola said. “The decisive part of the season is here ahead of us, in front of us, not far away, and we are going for it.”

Newcastle seeking consistency

Eddie Howe’s side slipped to ninth place with Saturday’s 4-1 loss to Arsenal, a mile off the sort of form that got them into the Champions League last term as a season best described as up and down continues. The best hope of returning to Europe next season may well lie with the FA Cup – a competition Newcastle are desperate to win to end their 55-year wait for major silverware. Although away from home, they should be firm favourites away to a Blackburn side still seeking a first win under new manager John Eustace. “This season can still be very special for us,” Howe said. “But we have to make it happen.”