Argentina's all-time leading scorer Messi was on the scoresheet alongside Rodrigo De Paul and Lautaro Martinez as the Albiceleste secured a 3-0 win in Monday's (AEDT) World Cup qualifier to move within six points of group leader Brazil.
Lionel Scaloni's men are now unbeaten in 24 games in all competitions, a run that includes a 1-0 win over Brazil in July's Copa America final and 10 games without defeat in its qualifying campaign on the road to Qatar 2022.
However, it may have been a different story against Uruguay had Emiliano Martinez not produced two big saves to keep out Luis Suarez with the game all square, the Aston Villa man going on to make six stops in total at El Monumental.
And Messi singled out the goalkeeper for particular praise after his side returned to winning ways on the back of Thursday's goalless draw with Paraguay.
"He is fundamental for us," Messi said. "When the pressure is on, he always responds. He did that again today. We know we have one of the best goalkeepers in the world and we are making the most of it.
"Uruguay had clear opportunities to score, even though we were in control. That's the sort of team they are. They are able to create danger out of nothing."
Argentina are now unbeaten at home under Scaloni in seven games in all competitions and have yet to lose at home to Uruguay in World Cup qualifying in six matches, winning the last five of those.
They are on the verge of booking a place at Qatar 2022 and Messi, whose six goals is level with Neymar and behind Bolivia's Moreno Martinez (eight) in the CONMEBOL top-scorers chart, is pleased with the strides being taken by his side.
"I think we are improving a lot in terms of the way we are playing and the way we are keeping possession," he said.
"We knew the results of the other qualifiers and that we needed to take six points from our next two home games. The fans here are great and it is beautiful to play here."
Argentina concludes its triple-header of October qualifiers with a home match against Peru on Friday (AEDT), before travelling to Uruguay on its return to action next month.