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Victory came courtesy of Lionel Messi's early penalty after Lucas Ocampos was impeded, with Argentina far from its best at La Bombonera.

A home game in Buenos Aires behind closed doors was an uncomfortable way to start the road to the finals, and Argentina's next game will be no easier as it travels to La Paz to face Bolivia on Wednesday (AEST).

Yet Scaloni, who pointed to seven players making their first appearances in FIFA World Cup qualifying games, was just happy to get the victory.

"We won, which is the most important thing to start a competition of this calibre," he said. "The conditions weren't easy, with a fast pitch and no fans, added to the difficulties of not having been together for so long.

"There are things to highlight and others to improve. I'm left with the desire, with the sacrifice. We will have time to work. The important thing was to get the result forward.

"There were many players who debuted in qualifiers today. It's not easy to play with this shirt and anxiety is typical of that situation.

"We were clear that this could happen because it was the first game. They took a great step when they made their debut and won."

Bolivia scored a 2-0 home win over Argentina in qualifying for the 2018 FIFA World Cup, and going to high altitude next week will be a serious test for Scaloni's team.

"We're going to see how the players recover and then we will think about Bolivia. We know that it is a game with conditions different from all the others," Scaloni said.

Argentina is now unbeaten in its past eight matches, while Messi took his tally to 71 goals for La Albiceleste.