Senegal recovered from a 1-0 first-leg deficit to land victory by the same margin at the Abdoulaye Wade Stadium on Wednesday (AEDT).
That meant the play-off, tied at 1-1 after 120 minutes of the second leg, went down to a battle of spot-kicks to decide who would go to Qatar 2022, and Salah missed Egypt's first penalty when he fired over the bar.
I mean, just look at this. Salah sails his penalty over… and surely anybody would, given the lasers.— Henry Bushnell (@HenryBushnell) March 29, 2022
Mane scores, Senegal wins the shootout, Egypt out of the World Cup pic.twitter.com/tgHmCmW8uu
Lasers flashed across the pitch and were directed at Egypt's star man, who could not find the focus to convert from 12 yards.
The first four penalties were missed, with Salah's the second of those, before both sides netted their third kicks.
Egypt's Mostafa Mohamed failed with the visitors' fourth penalty, seeing his shot blocked, and that allowed Mane to step up and crack a fierce spot-kick past Mohamed El Shenawy, booking a place in Friday's draw.