USA entered the away fixture unbeaten in eight World Cup qualifiers against Panama, including six wins, and enjoying a 13-match undefeated streak across all competitions.

But Panama had other ideas thanks to Anibal Godoy, whose 54th-minute header secured an unlikely victory in Panama City on the road to Qatar 2022.

In wild scenes, Godoy – who plays in MLS for Nashville – headed home Eric Davis' corner at the near post.

It was a rough outing for Gold Cup champion USA, who appeared out of sorts having failed to produce a single shot on target throughout the fixture at Estadio Rommel Fernandez.