Last season's runner-up is level on points with RB Leipzig and three behind leader United in a tightly-contested Group H.
Thomas Tuchel's side are without a quartet of first-team players for the crucial match at Old Trafford as Julian Draxler and Juan Bernat are also deemed unfit.
Icardi returned from a near-two-month lay-off with a knee injury in Sunday's (AEDT) 2-2 draw with Bordeaux.
However, PSG confirmed on its official website that the striker felt pain in his right adductor during a training session and will not be part of their travelling party.
Fellow attacker Sarabia was also a late substitute against Bordeaux but he has since sustained a muscle injury.
Draxler and Bernat have not featured since October and September respectively, meanwhile, and have been officially ruled out of the trip to Manchester.