Gerard Figueras, the secretary general of sport for the Generalitat de Catalunya, has recommended the game be held without fans present at Camp Nou on 19 March in a bid to combat the spread of the coronavirus.
The measure has already been implemented for Paris Saint-Germain's clash with Borussia Dortmund in the French capital, which takes place on Thursday (AEDT).
"The prudent course I would recommend is for the game to be played behind closed doors," Figueras said. "The decision is not yet made. Between today and tomorrow, there will be meetings between different government departments and the club."
Figueras says LaLiga champion Barca has been kept in the loop by authorities since early on Tuesday (AEDT).
"We talked this morning," he said. "We're trying to arrange the meeting between today and tomorrow, most likely tomorrow."
Italy has been more badly affected by the COVID-19 outbreak than other European countries, with 7,375 confirmed cases and 366 people killed.
Close to 16 million people have been ordered into effective quarantine in the northern areas of the country as the government attempts to control the spread of the virus.
All Serie A matches are being played behind closed doors until at least April, and Parma's match with SPAL was delayed while a proposal to suspend the league was considered just minutes before kick-off.
France has 1,116 confirmed cases, while there are 589 in Spain. Next weekend's Barcelona marathon has already been postponed until October.
Barca and Napoli drew the first leg 1-1, Antoine Griezmann's goal having cancelled out an opener from Dries Mertens.