Nadal needed three sets to secure the 1,000th ATP Tour-level victory of his career at the expense of Feliciano Lopez on Thursday (AEDT).

The top seed followed that up with a 6-1 7-6 (7-3) defeat of world number 61 Thompson in Bercy, reaching the quarter-finals of the tournament for an eighth time out of eight.

Nadal lost just 12 points behind his serve as Thompson failed to break the 20-time grand slam champion in the first meeting between the two on Thursday.

Ninth seed Carreno Busta stands in the way of Nadal and a place in the last four, as one of the all-time greats attempts to win the tournament for the first time.

Nadal was up against it in a battle with veteran Lopez before sealing a landmark win, but there was no slow start from the legendary left-hander in his third-round contest.

He held to love in the first game and in the fifth, then took a 5-1 lead with a deft volley at the net after drilling a rasping return and an inside-out forehand to Thompson's left.

The world number two wrapped up the set in only 32 minutes by winning a fifth consecutive game, but it was a different story in the second as Australian Thompson warmed to the task.

Thompson threw down his racket and was shaking his head after failing to win a set point before Nadal took it to a tie-break, which he won with a combination of thunderous winners and errors from his opponent.