Serbian star Djokovic, who is bidding to become the first player other than Rafael Nadal to win consecutive men's singles titles at Roland Garros since Gustavo Kuerten triumphed in 2000 and 2001, produced a ruthless display to blow away world No.195 Bedene in just one hour and 44 minutes.
Djokovic started as he meant to go on, launching an onslaught which forced Bedene to save five break points throughout his first two service games, before the Slovenian finally succumbed to a break in his third.
The No.1 seed was virtually perfect on his own serve, winning 94 per cent of points on first serve in the opening set before picking up another decisive break just three games into the second.
Despite appearing to struggle with the glare at times on a sun-bathed Court Philippe-Chatrier, Djokovic continued his professional display to move closer to victory, recording just three unforced errors to his opponent's 13 in the second set.
To the delight of some in the crowd, Bedene forced his first and only break point of the encounter in the opening game of the third set, only for Djokovic to power a fierce volley past the 32-year-old before recovering to hold serve.
The world No.1 did not look back from there, breaking to love in the fourth game before wrapping up a routine win after forcing two match points on Bedene's serve to set up a seventh career meeting with Schwartzman, against whom he boasts a 100 per cent record.