After suggestions lead-up events would be held in Victoria, reports on Tuesday said the Australian government was denying players entry in December.
Andrews reaffirmed his confidence the event at Melbourne Park would go ahead, although it remains uncertain exactly when, and under what conditions.
But he said on Thursday that any plan for the tournament would likely see it held in a bubble, which is what players endured during this year's US Open in New York and is an idea previously discussed by Australian Open tournament director Craig Tiley.
"I think a bubble arrangement would be an important feature of any final landing," Andrews told a news conference.
"Again, I'm not someone who runs tennis tournaments but logic tells you not only to protect public health, so keeping participants who've come from the rest of the world, which is on fire at the moment with the numbers we're seeing are just like nothing we've seen before, you've got to keep those people away from the Victorian community for a period of time and you also need to keep them away from each other to protect the integrity of the event.
"In the event that there's a positive case and you've not been bubbling people and having people separated then you might have to isolate half the field, which would of course make running the tournament very difficult so for all those reasons.
"I think that a bubble however constructed will be a feature and not just that, that's the way cricket will operate, that's the way the grand prix will operate some time later and many, many other events."
Victoria on Thursday recorded a 20th consecutive day without a coronavirus case.
There have been more than 1.3 million deaths from COVID-19 worldwide, with 907 in Australia.