Three-time grand slam champion Angelique Kerber became the first seed to exit the French Open as she lost to 18-year-old Anastasia Potapova.
Yulia Putintseva came from behind to beat Tamara Zidansek and claim her first WTA Tour title at the Nuremberg Cup.
Daria Gavrilova's Internationaux de Strasbourg campaign is over, the Australian eliminated in straight sets by Frenchwoman Chloe Paquet.
Second seed Aryna Sabalenka set up an Internationaux de Strasbourg quarter-final against Monica Puig after cruising through the round of 16.
Ashleigh Barty has withdrawn from the Internationaux de Strasbourg through injury, with under a week to go before the French Open.
Fresh from her tough three-set win over Viktoria Kuzmova, Australian tennis star Ash Barty discussed the strengths of each of her next possible opponents.