The Clermont star was ruled out of the week-four match with Wales after testing positive for COVID-19, but has now completed his isolation period and is back in the fold as France go in search of a Grand Slam.
Centre Yoram Moefana drops out of the 23-man selection as Les Bleus favour a six-two split between forwards and backs on the bench for the fixture at Stade de France.
Romain Taofifenua also returns among the replacements following his own positive coronavirus test earlier this month.
The hosts will complete a first Grand Slam since 2010 if they defeat Eddie Jones' visitors, and could still win the championship for the first time in a dozen years even in defeat.
Galthie will know what his side must do by the time they take to the field, with lone title rivals Ireland set to play before them against Scotland in Dublin.
France: Melvyn Jaminet, Damian Penaud, Gael Fickou, Jonathan Danty, Gabin Villiere, Romain Ntamack, Antoine Dupont, Gregory Alldritt, Anthony Jelonch, Francois Cros, Paul Willemse, Cameron Woki, Uini Atonio, Julien Marchand, Cyril Baille
Replacements: Peato Mauvaka, Jean-Baptiiste Gros, Mohamed Haouas, Romain Taofifenua, Thibaud Flament, Dylan Cretin, Maxime Lucu, Thomas Ramos