Without the injured Cristiano Ronaldo and Paulo Dybala and the ill Mario Mandzukic, it fell to Leonardo Bonucci to head in the opener midway through the first half.
Moise Kean scored his fourth goal in three games to seal the points late on, as Massimiliano Allegri's side cruised to victory.
The win took Juve 18 points clear at the top, with Napoli playing its game in hand against Empoli on Thursday (AEDT).
Juve overcame a sluggish start to take the lead 22 minutes in, Bonucci nodding in Federico Bernardeschi's corner from the left.
Blaise Matuidi headed a good chance for a second over the bar, and it was a miss that should have been punished six minutes before the break, when Joao Pedro side-footed high and wide.
Kean, who has been something of a revelation in Ronaldo's absence, had a quiet first hour but wasted a fine chance to make it 2-0 when he prodded a bouncing ball straight into the gloves of Alessio Cragno.
Substitute Alberto Cerri threatened with a header, but Kean ended the hosts' resistance when he tapped in Rodrigo Bentancur's drilled cross from the right with five minutes remaining.