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Title battles in England, Spain and Italy could be too close to call, while France and Germany will see rivals trying to knock Paris Saint-Germain and Bayern Munich off their respective perches – while there is even more set to occur in the fight for European qualification and to avoid the drop.
Central to these battles will be the players, both new signings and established members of the old guard, and here are 10 to watch in the year ahead.
Ousmane Dembele – Barcelona
Previously considered to be one of the biggest pieces of evidence on Barcelona's transfer failings in recent years, Dembele turned a corner in the second half of last season to finish the campaign as one of Xavi's most important players.
Dembele finished with 13 assists in LaLiga last term, the most in the competition, 11 of which came in the final 15 games of the season – with the tally being more in that run from February than he accumulated across all competitions combined in the previous two seasons.
Handed a fresh new contract, all eyes will be on Dembele to see whether he is back to his best or whether the former Borussia Dortmund winger, who now has Raphinha for competition, merely had a purple patch.
Matthijs de Ligt – Bayern Munich
It has now been three years since De Ligt shone with the Ajax side that reached the Champions League semi-finals, where his performances made him one of the most coveted players in world football.
Stability was never quite found at Juventus, however, with shoulder injuries hampering his progress and the defender himself admitting the style was a "bit different" in Turin to what he experienced with Ajax.
Now at Bayern, De Ligt will look to return to the heights he was once at and is expected to form an exciting partnership with Dayot Upamecano.
Rafael Leao – Milan
In Milan's title-winning campaign last term, Leao was the team's joint-leading scorer in Serie A with 11 goals, alongside Olivier Giroud, but that was way off the pace in the overall charts as 15 players found the net more times.
Milan's total tally for goals in 2021-22 was 69, less than three of their rivals in the top five, and pressure is on Stefano Pioli's side to improve that return – with the signing of Divock Origi showing the desire to improve their return in the final third, with rivals Inter having strengthened by bringing Romelu Lukaku back to San Siro on loan.
It may all fall upon Leao, however, with the 23-year-old needing to show consistency in order to prove a significant venture into the market next year to replace veterans Giroud and Zlatan Ibrahimovic is not required.
Djed Spence – Tottenham
Middlesbrough will likely wonder what might had been if they retained Spence's services, having loaned him to Championship rivals Nottingham Forest and seeing him play a key part in their promotion back to the big time.
From September, the only two games Spence missed during Forest's league campaign were the two clashes with his parent club and his displays, including those in the FA Cup against the likes of Arsenal, made him hot property.
Spurs ultimately signed the England U21 international, who could be a contender to break into Gareth Southgate's World Cup squad if he quickly finds his feet in north London. He is a right-back, after all...
Darwin Nunez – Liverpool
Liverpool's prowess in the transfer market is facing its biggest test under Jurgen Klopp, who is looking to rejuvenate what has been a brilliant attacking trio with Sadio Mane moving on and Roberto Firmino's future uncertain.
Having signed Luis Diaz in January, the Reds raided a Portuguese giant again – this time Benfica – for Nunez.
Nunez scored six Champions League goals in the 2021-2022 season and plundered a further 26 in the league, averaging a goal every 76 minutes. Nunez certainly has the capability to fill Klopp's Mane-shaped void, even if his style is slightly different to the Senegal attacker.
Matteo Guendouzi – Marseille
Swiftly breaking onto the scene at Arsenal but just as quickly earning himself a bad-boy reputation, Guendouzi flourished in his loan spell with Marseille last season and has now made the switch permanent.
The France international featured in every game for Marseille in the 2021-2022 season, starting in 35 of his 38 Ligue 1 appearances, and forced his way back into contention to make Didier Deschamps' squad on a regular basis ahead of Les Bleus' World Cup defence in Qatar.
Guendouzi's growing maturity saw him captain Marseille in a 2-0 defeat against Lille last season and the forthcoming campaign may continue his redemption arc.
Adam Hlozek – Bayer Leverkusen
A name that will be familiar to Football Manager enthusiasts, Hlozek has earned his big move to one of Europe's top leagues after leaving Sparta Prague in his homeland for Bayer Leverkusen and the challenges of the Bundesliga.
Capable of playing across the front line, Hlozek heads to Germany with a stellar record of 29 goals and 30 assists in 91 league appearances in the top-tier in the Czech Republic.
Add in the 24 goals that compatriot Patrik Schick netted for Leverkusen last season along with the creativity of Florian Wirtz from midfield and the result is one that could be extremely exciting.
Vinicius Junior – Real Madrid
A formidable season for Vinicius saw the Brazilian net 17 goals and contribute 10 assists during Real Madrid's La Liga title-winning campaign, only being outscored by team-mate Karim Benzema in the league.
Benzema, who was one of only two players to get more assists than Vinicius last season, is now in the twilight years of his career and will soon surely hand the mantle to the next star forward at the Santiago Bernabeu – with Vinicius near-certain to be that man now Kylian Mbappe has decided to remain in Paris for the time being.
In a World Cup year, Vinicius could enjoy a campaign that sees him take the leading man tag for both club and country come the end of the season.
Hugo Ekitike – Paris Saint-Germain
Arriving into an attacking that already boasts Mbappe, Neymar and Lionel Messi, it remains to be seen just how much football 20-year-old Hugo Ekitike will manage to play for Christophe Galtier's side.
Moving initially on loan, Ekitike, who was also a target for Newcastle United, is certainly one for the future.
With 10 goals and four assists for Reims last term, Ekitike has shown his prowess in the final third and could be a valuable asset in the hunt to end the elusive wait for a Champions League crown.
Samuele Ricci – Torino
Long touted as the next star in Italy's midfield, Samuele Ricci has moved on from Empoli but, to the surprise of some, did not take the leap to one of Serie A's big guns and instead continued his development by joining Torino in January.
Ricci featured 13 times for Torino, including nine starts in what was a stellar breakout year in Italy's top tier, with the 20-year-old having previously been crowned Serie B's best player in the 2020-21 season.
Breaking into Italy's squad in 2022, Ricci's meteoric rise should continue, and he may find himself coveted by some of the biggest clubs across Europe.