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The 21-year-old Stade Toulousain man replaces Matthieu Jalibert, who misses out with the head injury sustained during their thrilling 32-30 win over Wales last Sunday.
Ntamack was the 2020 Six Nations player of the Championship and would have been first choice in this campaign had he not suffered a jaw injury in December which gave Jailbert the chance to feature.
The match was originally scheduled for February 28 but a COVID-19 outbreak in the French camp saw the fixture postponed.
France must record a bonus-point victory, and win by at least 21 points, or claim a 20-point win and score at least six tries, to snatch the title away from Wales.
If France scores precisely five tries and is victorious by 20 points the Championship will be shared for the first time since 1988.
In a twist of circumstance, it was Wales and France who shared the honours on that occasion, when the tournament was the Five Nations.
The return of Ntamack is one of two enforces changes, and five overall, made by France coach Fabien Galthie.
Paul Willemse is suspended after his red card against Wales so Galthie has decided to pair Swan Rebbadj and Bernard Le Roux at second row, with Romain Taofifenua named among the replacements.
Anthony Jelonch has been selected ahead of Dylan Cretin at blindside flanker, while centre Arthur Vincent comes in at inside centre as Gael Fickou moves to the wing with Teddy Thomas dropped to the bench.
"The Scots have the best defence in the tournament. They are very well organised and well disciplined," Galthie said.
"We must not be wrong about what is at stake. You have to win the match, the rest will come later. We have to focus on performance and winning the match, we'll see what happens next."
Scotland coach Gregor Townsend makes four changes to his XV as outside centre Chris Harris, scrum-half Ali Price, hooker George Turner and fly-half Finn Russell return.
Russell is back from concussion which means captain Stuart Hogg returns to full-back while Sean Maitland stands aside.
Huw Jones, Scott Steele and Dave Cherry will be on the bench, where they are joined by Adam Hastings, who may feature for the first time in the tournament after injury and suspension absences.
"The match against France provides us with an opportunity to finish the Six Nations in our highest position in its history," Townsend told Scottish Rugby.
"This is a great opportunity for us to take on France, at home in Paris, as they also look to end the championship on a high."
France: Brice Dulin, Damian Penaud, Virimi Vakatawa, Arthur Vincent, Gael Fickou, Romain Ntamack, Antoine Dupont; Cyril Baille, Julien Marchand, Mohamed Haouas, Bernard Le Roux, Swan Rebbadj, Anthony Jelonch, Charles Ollivon, Gregory Alldritt.
Replacements: Camille Chat, Jean-Baptiste Gros, Uini Atonio, Romain Taofifenua, Dylan Cretin, Baptiste Serin, Anthony Bouthier, Teddy Thomas.
Scotland: Stuart Hogg, Darcy Graham, Chris Harris, Sam Johnson, Duhan van der Merwe, Finn Russell, Ali Price; Rory Sutherland, George Turner, Zander Fagerson, Sam Skinner, Grant Gilchrist, Jamie Ritchie, Hamish Watson, Matt Fagerson.
Replacements: Dave Cherry, Oli Kebble, Simon Berghan, Alex Craig, Nick Haining, Scott Steele, Adam Hastings, Huw Jones.