Jacques Brunel's side beat Scotland 27-10 in this season's Six Nations and this was an even more sapping experience for their visitors in Nice.
The damage was done by first-half tries from Alivereti Raka, Maxime Medard and Gregory Alldritt, with Medard adding a second before Antoine Dupont went over with an hour played.
Gregor Townsend's men host the same opponent next weekend at Murrayfield, where they will need to make a better start than the botched lineout that allowed Raka to gleefully charge over on the end of Wesley Fofana's second-minute pass.
Medard touched down in the corner to make it 15-0, Camille Lopez having dispatched his initial attempts from the tee.
Adam Hastings kicked Scotland's solitary points but was in the sin-bin when the France pack obliterated its opponent in a rolling maul, with Alldritt the beneficiary.
Francois Cros was the latest home player to tear through Scotland's meagre defensive efforts in the 54th minute, allowing Medard a gleeful run to the line.
Dupont benefitted from Damian Penaud's mazy run, with Lopez adding the extras before France eased to the close, giving Townsend plenty to think about before the sides reconvene in Edinburgh.