Ford made his return from an Achilles injury off the bench in the 18-7 victory over Ireland at Twickenham last weekend, but will take the number 10 shirt at Parc y Scarlets.
Captain Owen Farrell shifts to inside centre, partnering Henry Slade after Ollie Lawrence was omitted from the squad due to a hip injury.
The England side is otherwise unchanged as Eddie Jones' men look to make it three wins out of three and seal top spot.
Luke Cowan-Dickie and Anthony Watson have been named on the bench after recovering injuries, while Ben Earl, Ellis Genge, Jonny Hill, Dan Robson, Will Stuart and Jack Willis are the other replacements.
Captain Alun Wyn Jones returns to the Wales starting line-up in Llanelli following the win over Georgia.
Under-fire head coach Wayne Pivac has made eight changes to his side, with Leigh Halfpenny replacing Liam Williams at full-back, Josh Adams starting on the wing and Lloyd Williams and Dan Biggar getting the nod as the half-back pairing.
England team: Elliot Daly, Jonathan Joseph, Henry Slade, Owen Farrell (captain), Jonny May, George Ford, Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, Joe Launchbury, Tom Curry, Sam Underhill, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Ellis Genge, Will Stuart, Jonny Hill, Ben Earl, Jack Willis, Dan Robson, Anthony Watson.
Wales team: Leigh Halfpenny, Louis Rees-Zammit, Nick Tompkins, Johnny Williams, Josh Adams, Dan Biggar, Lloyd Williams; Wyn Jones, Ryan Elias, Samson Lee, Jake Ball, Alun Wyn Jones (captain), Shane Lewis-Hughes, James Botham, Taulupe Faletau.
Replacements: Elliot Dee, Rhys Carre, Tomas Francis, Will Rowlands, Aaron Wainwright, Rhys Webb, Callum Sheedy, Owen Watkin.