Huddersfield had gone 658 minutes without a home league goal, Tom Ince the last man to find the net at the John Smith's Stadium back in April.
However, a Timothy Fosu-Mensah own goal ended that barren spell in the 29th minute, and Fulham rarely looked like mounting a response as Huddersfield claimed a first win of the campaign.
Andre Schurrle did find the net for the visitors, but only after Aleksandar Mitrovic had strayed offside, the linesman correctly flagging as Fulham slipped to a deserved defeat that will intensify the pressure on head coach Slavisa Jokanovic.
Only the woodwork denied Huddersfield an opener as Philip Billing's rasping left-footed drive clattered against the crossbar.
Steve Mounie headed over from close range before a deflected Alex Pritchard effort forced Sergio Rico to turn behind, but the deadlock was broken shortly afterwards.
Fulham failed to clear the second of two successive corners and Christopher Schindler took advantage by glancing a header into the bottom-right corner, though the last touch was adjudged to have come off Fosu-Mensah.
Florent Hadergjonaj was fortunate not to concede a penalty when he appeared to pull down Denis Odoi at a free-kick, though Huddersfield had an appeal for a spot-kick of its own waved away when Hadergjonaj was felled by Ryan Sessegnon.
Pritchard flashed a half-volley over in a second period of few chances, Schurrle seeing his fine finish at the other end chalked off as Fulham was condemned to a fifth straight league defeat.