Pep Guardiola has tested positive for coronavirus and will miss Manchester City's FA Cup tie against Swindon Town, the Premier League champion has confirmed.
Guardiola and his assistant Juanma Lillo recorded positive test results on Tuesday, and both are now isolating.
City now has 21 members of its squad – seven players and 14 backroom staff – in isolation.
Fourth-tier Swindon host City in the FA Cup third round on Friday, and assistant coach Rodolfo Borrell will take charge of the Premier League leaders.
Guardiola joins three fellow Premier League managers who have had to isolate in the last week.
Arsenal manager and Guardiola's former assistant Mikel Arteta had to watch on from home as the Gunners lost 2-1 to City on New Year's Day.
Jurgen Klopp, meanwhile, was absent for Liverpool's draw with Chelsea on Sunday while on Friday (AEDT), Burnley confirmed Sean Dyche was isolating after testing positive.