Ramos ended a 16-year association with Real Madrid as he joined PSG in July on a free transfer, but he has not played since Los Blancos' Champions League semi-final loss against Chelsea in early May.
Reports suggested the centre-back, who signed a two-year deal at the Parc des Princes, could make his debut on Friday against Angers. However, PSG have confirmed that is not the case.
The Ligue 1 champion released an update on Friday (AEDT), announcing Ramos is still in individual training with a view to joining the squad in 10 days, which means he will also seemingly miss Tuesday's Champions League clash with RB Leipzig and the trip to Marseille for Le Classique on 25 October.
When asked about the Spain international's prolonged absence, Pochettino said at his pre-match news conference: "I am convinced he will get back to his best.
"It is clear that every player, in this case Sergio Ramos, does not enjoy the situations when they are out and unable to train with their team-mates and play for such a long time.
"He is suffering but is strong mentally and he is coping with it as well as he can. The performance team are helping him stay at a high level and full of motivation to get over this problem."
Ramos appeared in 469 top-flight games for Madrid – with only three players racking up more appearances in the competition for Los Blancos.
He lifted 22 trophies at the club – with only Paco Gento (23) bettering that haul – and started all of his 129 Champions League matches, the most of any player in the competition without a single substitute appearance.
When fit, Pochettino will not just have a defensive leader to call upon, Ramos is also one of the best defenders in terms of attacking returns.
Since the turn of the century, Ramos is the only defender to score 100 goals while playing in one of Europe's top five leagues, and only three players have netted more headed LaLiga goals in that period than the 35-year-old (39).