Ramos moved to Paris Saint-Germain on a free transfer in July, but is yet to make an appearance for Mauricio Pochettino's side because of a knee injury.
The centre-back made a huge step on his road to recovery as he was an unused substitute in Thursday's (AEDT) UEFA Champions League loss against Manchester City.
The former Real Madrid star could be in line for his debut away to Saint-Etienne, where PSG is unbeaten in 12 league games, with its most recent loss coming in September 2008.
But Ramos feels he can play on for a lot longer if his mental state can hold out, as he believes he is physically fit enough to compete for many more years.
"I think I can continue playing for four or five years," Ramos said.
"The most important thing is that my head holds. I hope I don't have any more physical problems."
The 35-year-old ended a 16-year association with Madrid when he left for France, but he has not played since Los Blancos' UEFA Champions League loss against Chelsea in early May.
Numerous reports have suggested an earlier return for Ramos, who signed a two-year contract at PSG, although Monday (AEDT) could finally be the day he makes his bow.
When fit, Pochettino will have one of football's best defenders in terms of attacking returns to call upon, but Ramos's comeback will also be a sweet personal victory for the Spain international.
"I believed in myself and in work," he continued. "I focus on giving the club back the trust it has placed in me. I hope to reach my best level.
"At the end are difficult moments, moments of loneliness. Whole hours in the gym with the physiotherapist, with the physical trainer. You constantly have negative thoughts that sometimes make you doubt."