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Sevilla could have become the first team to draw three successive away games at the Wanda, but Atletico produced a vintage display of clinical finishing and resolute defending as it improved its position at the top of the table.
Atleti edged an even first half and went ahead through Angel Correa's clinical finish with just over quarter of an hour played, though Sevilla did trouble Jan Oblak through Ivan Rakitic and Youssef En-Nesyri.
The visitor dominated proceedings in the second period but struggled to find a way through Atletico's famously shrewd defence. Saul Niguez put the game beyond Sevilla in the latter stages.
Sevilla looked bright in the opening exchanges as Rakitic tested Oblak early on, before going behind in the 17th minute – Correa picking out the bottom-right corner with a snapshot on the swivel that caught Yassine Bounou unsighted in goal.
Atleti was fortunate at the other end soon after.
Oblak initially rushed out to thwart En-Nesyri and the ball fell kindly to Marcos Acuna, but the left-back shot wide of the empty net with the goalkeeper stranded.
Luis Suarez then threatened before the half-hour mark, but his close-range volley was well blocked by Bounou.
En-Nesyri tried his luck from a tight angle early in the second half, but Oblak had little issue making the save.
While Sevilla saw much of the ball, that En-Nesyri effort was hardly the start of an onslaught and Atleti picked it off 14 minutes from time.
Marcos Llorente found space behind Acuna and Oscar Rodriguez failed to intercept his cutback, which came to Saul and he swept in from 20 yards to seal the points.
